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Dietary Patterns an...
Dietary Patterns and Cognitive Dysfunction in a 12-Year Follow-up Study of 70 Year Old Men
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- Olsson, Erika (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Karlström, Brita (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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- Byberg, Liisa (author)
- Uppsala universitet,Ortopedi
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- Cederholm, Tommy (author)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism
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- Sjögren, Per (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 43:1, s. 109-119
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
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- Background:Adherence to dietary patterns has been associated with cognitive decline and dementia, but studies are inconsistent.Objective:Dietary patterns, i.e., WHO recommendations (Healthy Diet Indicator), a Mediterranean-like diet (modified Mediterranean Diet Score, mMDS), and a low carbohydrate high protein diet (LCHP), were related to incident cognitive dysfunction, as indicated by Alzheimer's disease (AD), all-type dementia, and all-type cognitive impairment, in a cohort of 1,138 elderly Swedish men.Methods:Dietary patterns were derived from 7-day records. Risk relations were calculated by Cox and logistic regression analyses, adjusted for potential confounders. Sensitivity analysis was performed in a subpopulation (n = 564) with energy intake according to the Goldberg cut-off. Results:During a mean follow-up of 12 years, 84, 143, and 198 men developed AD, all-type dementia, and all-type cognitive impairment, respectively. There was no association between Healthy Diet Indicator and any of the outcomes. Hazard ratios associated with 1 standard deviation (SD) increment in the LCHP score were 1.16 (95% confidence interval [CI]: 0.95, 1.43) for AD and 1.16 (95% CI: 0.99, 1.37) for all-type dementia. mMDS was not associated with dementia diagnosis. Odds ratio (OR)/1 SD increase for mMDS and all-type cognitive impairment was 0.82 (95% CI: 0.65, 1.05). In the subpopulation OR for mMDS and all-type cognitive impairment was 0.32 (95% CI: 0.11, 0.89).Conclusion:We found no strong associations with development of cognitive dysfunction for any of the dietary patterns investigated. However, there was a potentially beneficial association for a Mediterranean-like diet on the development of cognitive dysfunction in the subpopulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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